Gene therapy has the potential to be a one-shot treatment that could reverse blindness, restore blood-clotting function to hemophiliacs, or even cure rare diseases outright. Read more here.
In May 2012, the University of California, Berkeley, filed a patent application for biochemist Jennifer Doudna and the University of Vienna’s Emmanuelle Charpentier, then of Umeå University in Sweden, based on their seminal observation that the bacterial CRISPR-Cas9 gene-editing system can be used to target different sequences of DNA by reprogramming the system’s small homing […]
Food and Drug Administration commissioner Scott Gottlieb said the FDA is hurrying to modernize the way it evaluates a flood of new drug applications derived from the fast-growing fields of gene and cell therapy. Read more here.
In the small city of Terni in central Italy, researchers are putting the final touches on what could be the world’s most sophisticated mosquito cages. Read more here.
Scientists face tough decisions when the latest gene-editing findings don’t match up with the results of other techniques. It seemed like the perfect plan. Read more here.
The Key to Unlocking Precision Medicine NEJM An IOM committee focused on biomarkers for molecularly targeted therapies has issued recommendations about regulatory, reimbursement, and clinical practice issues, in order to guide precision medicine in advancing the care of patients with cancer and other diseases. This article was published on June 1, 2016, at NEJM.org. Disclosure forms […]
If you’ve ever had a Labrador retriever, you know about one of the breed’s notable traits: an unrelenting appetite. The dogs will devour anything from socks to rocks, and given the chance, they can be prone to eat themselves into obesity. By one estimate, nearly 60 percent of all Labradors are overweight or obese. […]
Mosquitoes and other organisms normally have a 50 percent chance of passing along a gene to an offspring. A gene drive copies and pastes itself into chromosomes from both parents, ensuring it gets passed on more often. Mosquitoes and invasive species can rest easy — for now. Genetic technology called gene drives could wipe out […]
Radical treatment for rare ‘bubble boy’ disorder has a 100% survival rate The European Commission has given approval for British drug firm GlaxoSmithKline to produce the world’s first gene therapy treatment for children. GSK will produce Strimvelis, the first stem cell gene therapy to treat patients with severe combined immunodeficiency caused by adenosine deaminase deficiency […]
Immune Engineering – That may just be the start The doctors looking at Layla Richards saw a little girl with leukemia bubbling in her veins. She’d had bags and bags of chemotherapy and a bone marrow transplant. But the cancer still thrived. By last June, the 12-month-old was desperately ill. Her parents begged—wasn’t there anything? […]
On São Miguel Island, in the Azores archipelago in the middle of the North Atlantic, lives a curious Brazilian expat. Known as Pontoscolex corethrurus, this tropical worm cannot tolerate the isle’s temperate climate. And yet it survives there in two areas: in artificially warmed pineapple greenhouses and the soil within an active volcano. Read more here
Advisers to the US Food and Drug Administration (FDA) have paved the way for the agency’s first approval of a gene therapy to treat a disease caused by a genetic mutation. Read more here.
In 2010, 5-year-old Emily Whitehead was diagnosed with acute lymphoblastic leukemia (ALL). Read more here.
Everyone at the meeting had one thing in common: a ticking time bomb buried in their DNA. Read more here.
Crispr Patent-Holders Move Toward Easing Access to Gene-Editing Technology Read more here.
Rewriting the code of life has never been so easy. In 2012 scientists demonstrated a new DNA-editing technique called Crispr. Five years later it is being used to cure mice with HIV and hemophilia. Read more here.
Scientists create a part-human, part-pig embryo, raising the possibility of interspecies organ transplants
For the first time, scientists have grown an embryo that is part-pig, part-human. The experiment, described Thursday in the journal Cell, involves injecting human stem cells into the embryo of a pig, then implanting the embryo in the uterus of a sow and allowing it to grow. Read more here.
The controversial laboratory tool known as CRISPR may have found a whole new world to conquer. Read more here.
On a November evening last year, Jennifer Doudna put on a stylish black evening gown and headed to Hangar One, a building at NASA’s Ames Research Center that was constructed in 1932 to house dirigibles. Read more here.
Earth is in the midst of its sixth mass extinction: Somewhere between 30 and 159 species disappear every day, thanks largely to humans, and more than 300 types of mammals, birds, reptiles, and amphibians have vanished since 1500. Read more here.
Last week a panel of judges at the U.S. Patent and Trademark Office in Alexandria, Virginia, heard arguments as to who should own the rights to the century’s biggest biotechnology invention to date, a precise gene-editing system called CRISPR-Cas9 that has the potential to treat serious human genetic disorders and create designer crops that resist […]