Arming Synthetic Bacteria Against Cancer

mouse

Researchers engineer bacteria that deliver an anti-tumor toxin in mice before self-destructing.

A synthetic genetic circuit programmed into an attenuated Salmonella enterica subspecies can be used to systemically deliver an anti-tumor toxin into mice with cancer. The circuit allows the bacterial cells inside a tumor to synchronously self-destruct by lysis, releasing the toxin directly in the tumor. The treatment of mice with the engineered bacteria is described by researchers at the University of California, San Diego (UCSD), today (July 20) inNature, pointing to a way to harness bacteria for cancer drug delivery. Read more here.


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